UW-Stevens Point at Wausau 518 South 7th Avenue Wausau, WI 54401 71. University of Wisconsin-Stevens Point 2100 Main Street Stevens Point, WI 54481-3897. The authors have declared no competing interest. Housing Dining Get Involved Health Services Campus Police Student Life Sustainability. The pipeline has been integrated into the web portal. Our method and pipeline could benefit researchers worldwide who work in molecular biomedicine and drug discovery, and substantially increase the throughput of the cryo-EM model building. The experiments showed improved accuracy and efficiency when benchmarking the performance on independent experimental maps of protein-DNA/RNA complexes and demonstrated the promising future of macromolecular modeling from cryo-EM maps. Accessibility We are committed to providing equal access to library collections, services, and facilities for all library users.
Learn about citing > Career development 250,000 science, technology and health jobs to advance your career. We recently developed DeepTracer-2.0, an artificial intelligence-based pipeline that can build amino acid and nucleic acid backbones from a single cryo-EM map, and even predict the best-fit residues according to the density of side chains. Learn about the library > Easy referencing Generate references, citations and bibliographies in a whole range of journal styles with just a few clicks. However, the model building of large macromolecular complexes is often difficult and time-consuming. The structural information of these macromolecular complexes forms the foundation for understanding the molecular mechanism including many human diseases. Cryo-electron microscopy (cryo-EM) allows a macromolecular structure such as protein-DNA/RNA complexes to be reconstructed in a three-dimensional coulomb potential map.
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